CBB1007 trihydrochloride

Chemical Structure : CBB1007 trihydrochloride

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货号: PC-24001Not For Human Use, Lab Use Only.

CBB1007 trihydrochloride is a cell-permeable, potent, reversible and substrate competitive (LSD1, KDM1A) selective inhibitor with IC50 of 5.27 uM.

规格	价格	库存	数量
10 mg		Get quote
25 mg		Get quote
50 mg		Get quote

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生物&药学活性

CBB1007 trihydrochloride is a cell-permeable, potent, reversible and substrate competitive (LSD1, KDM1A) selective inhibitor with IC50 of 5.27 uM.
CBB1007 efficiently can block LSD1-mediated demethylation of H3K4Me2 and H3K4Me (IC50 ≤ 5 μM) with no effect on H3K4Me3 and H3K9Me2, and LSD2 and JARID1A activities.
CBB1007 induces activation of epigenetically suppressed CHRM4/M4-ArchR and SCN3A genes in F9 cells (IC50 ≤ 3.74 μM).
CBB1007 preferentially arrests the growth of pluripotent tumors with minimal effect on non-pluripotent cancer or normal somatic cell.

物理化学性质&存储条件

分子量	644.00
分子式	C27H37Cl3N8O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzoic acid, 3-[[4-[4-(aminoiminomethyl)benzoyl]-1-piperazinyl]carbonyl]-5-[[4-(aminoiminomethyl)-1-piperazinyl]methyl]-, methyl ester, hydrochloride (1:3)

参考文献

1. Jing Wang, et al. Cancer Res. 2011 Dec 1;71(23):7238-49.