CBB1007

Chemical Structure : CBB1007

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货号: PC-24000Not For Human Use, Lab Use Only.

CBB1007 is a cell-permeable, potent, reversible and substrate competitive LSD1 selective inhibitor with IC50 of 5.27 uM.

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生物&药学活性

CBB1007 is a cell-permeable, potent, reversible and substrate competitive (LSD1, KDM1A) selective inhibitor with IC50 of 5.27 uM.
CBB1007 efficiently can block LSD1-mediated demethylation of H3K4Me2 and H3K4Me (IC50 ≤ 5 μM) with no effect on H3K4Me3 and H3K9Me2, and LSD2 and JARID1A activities.
CBB1007 induces activation of epigenetically suppressed CHRM4/M4-ArchR and SCN3A genes in F9 cells (IC50 ≤ 3.74 μM).
CBB1007 preferentially arrests the growth of pluripotent tumors with minimal effect on non-pluripotent cancer or normal somatic cell.

物理化学性质&存储条件

分子量	534.62
分子式	C27H34N8O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	Methyl 3-(4-(4-carbamimidoylbenzoyl)piperazine-1-carbonyl)-5-((4-carbamimidoylpiperazin-1-yl)methyl)benzoate

参考文献

1. Jing Wang, et al. Cancer Res. 2011 Dec 1;71(23):7238-49.

CBB1007

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物理化学性质&存储条件

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CBB1007

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