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首页-小分子抑制剂&激动剂-Tyrosine Kinase-BTK-CB988
CB988

Chemical Structure : CB988

CAS No.:

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CB988 (CB 988, CB-988)

货号: PC-61951Not For Human Use, Lab Use Only.

CB988 is a potent, highly selective, non-covalent Btk inhibitor targering ibrutinib-resistant Btk C481S mutant (IC50=0.6 nM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    CB988  is a potent, highly selective, non-covalent Btk inhibitor targering ibrutinib-resistant Btk C481S mutant (IC50=0.6 nM).
    CB988 inhibits activated Btk and unactivated Btk with IC50 of 0.78 and 0.09 nM, strongly reduces p-Tyr223 and the proliferation of OCI-Ly10 cells.

    物理化学性质&存储条件

    分子量
    分子式
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    参考文献

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