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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-IRE1-CB5305630
CB5305630

Chemical Structure : CB5305630

CAS No.: 342388-50-5

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CB5305630 (CB-5305630, CB 5305630)

货号: PC-70079Not For Human Use, Lab Use Only.

CB5305630 is a potent and noncompetitive IRE1 RNase inhibitor with IC50 of 60 nM in the FRET-derepression assay.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    CB5305630 is a potent and noncompetitive IRE1 RNase inhibitor with IC50 of 60 nM in the FRET-derepression assay.
    CB5305630 also inhibits the cleavage of a radiolabeled Xbp1-derived RNA probe in vitro.

    物理化学性质&存储条件

    分子量 280.278
    分子式 C16H12N2O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (E)-7-hydroxy-4-methyl-8-((pyridin-2-ylimino)methyl)-2H-chromen-2-one

    参考文献

    1. Cross BC, et al. Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):E869-78.

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