CB-002 |CAS:61034-15-9 Probechem Biochemicals

Chemical Structure : CB-002

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CB-002 (CB002)

货号: PC-60218Not For Human Use, Lab Use Only.

CB-002 (CB002) is a novel small molecule that restores p53 function in mutant p53-expressing colorectal cancer cells without toxicity to normal human fibroblasts.

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生物&药学活性

CB-002 (CB002) is a novel small molecule that restores p53 function in mutant p53-expressing colorectal cancer cells without toxicity to normal human fibroblasts.
CB-002 (CB002) increases expression of endogenous p53 target genes NOXA, DR5, and p21 and cell death.
CB-002 (CB002) decreases the stability of mutant p53 in RXF393 cancer cells and an exogenously expressed R175H p53 mutant in HCT116 p53-null cells.

物理化学性质&存储条件

分子量	271.28
分子式	C13H13N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8-Anilino-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione

参考文献

1. Hernandez-Borrero LJ, et al. Cell Cycle. 2017 Jul 27:0. doi: 10.1080/15384101.2017.1346762.

2. Richardson C, et al. Cell Cycle. 2017 Jul 27:0. doi: 10.1080/15384101.2017.1356514.

CB-002 (CB002)

生物&药学活性

物理化学性质&存储条件

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CB-002 (CB002)

生物&药学活性

物理化学性质&存储条件

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