CAY10786 | GPR52 antagonist | Probechem Biochemicals

Chemical Structure : CAY10786

CAS No.: 1239987-91-7

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CAY10786 (GPR52 antagonist Comp-43)

货号: PC-72128Not For Human Use, Lab Use Only.

CAY10786 (GPR52 antagonist Comp-43) is a highly potent and specific GPR52 antagonist with IC50 of 0.63 uM.

规格	价格	库存
10 mg	￥980	In stock
25 mg	￥1680	In stock
50 mg	￥2780	In stock
100 mg		Get quote

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生物&药学活性

CAY10786 (GPR52 antagonist Comp-43) is a highly potent and specific GPR52 antagonist with IC50 of 0.63 uM.
Comp-43 showed no effects on the cAMP elevation or calcium response stimulated by other GPCRs (β2AR, GCGR, GLP-1R, CCR5, α-1D adrenergic receptor, and dopamine D2 receptor (DRD2).
Comp-43 reduces mHTT levels by targeting GPR52 and promotes survival of mouse primary striatal neurons.
Comp-43 not only reduces mHTT levels but also rescues Huntington's disease (HD)-related phenotypes in HdhQ140 mice.

物理化学性质&存储条件

分子量	242.336
分子式	C15H14OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO (2.4 mg/mL)
Chemical Name/SMILES	(2E)-5-phenyl-1-(2-thienyl)-2-penten-1-one

参考文献

1. Hidetoshi Komatsu. J Med Chem. 2021 Jan 28;64(2):938-940.

2. Congcong Wang, et al. J Med Chem. 2021 Jan 28;64(2):941-957.

CAY10786 (GPR52 antagonist Comp-43)

生物&药学活性

物理化学性质&存储条件

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CAY10786 (GPR52 antagonist Comp-43)

生物&药学活性

物理化学性质&存储条件

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