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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Stearoyl-CoA Desaturase (SCD)-CAY10566
CAY10566

Chemical Structure : CAY10566

CAS No.: 944808-88-2

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CAY10566 (CAY 10566, SCD1 inhibitor 28c)

货号: PC-20383Not For Human Use, Lab Use Only.

CAY10566 is a potent, selective and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor with IC50 of 4.5 and 26 nM for mouse and human SCD1, respectively.

规格 价格 库存 数量
5 mg ￥1480 In stock
10 mg ￥2280 In stock
25 mg ￥3980 In stock
50 mg ￥5980 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CAY10566 is a potent, selective and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor with IC50 of 4.5 and 26 nM for mouse and human SCD1, respectively.
CAY10566 shows minimal against 75 different receptors, transporters, and ion channels in Cerep HTP screen.
CAY10566 showed a dose-dependent inhibition of SCD1-mediated conversion of saturated LCFA-CoAs to monounsaturated LCFA-CoAs in HepG2 cells (IC50, 7.9 nM as measured by C17:1/C17:0, or 6.8 nM as measured by [13C]-C16:1/[13C]-C16:0).
CAY10566 induced ATF4 mRNA, phosphorylated ATF4 protein, and total ATF4 protein in vascular smooth muscle cells (VSMC).
CAY10566 decreases CHIKV genome replication.

物理化学性质&存储条件

分子量 389.82
分子式 C18H17ClFN5O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(6-(4-(2-Chloro-5-fluorophenoxy)piperidin-1-yl)pyridazin-3-yl)-5-methyl-1,3,4-oxadiazole

参考文献

1. Liu G, et al. J Med Chem. 2007 Jun 28;50(13):3086-100.

2. Masuda M, et al. J Lipid Res. 2012 Aug;53(8):1543-52.

3. Bakhache W, et al. Antiviral Res. 2019 Dec;172:104642.

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