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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Nitric Oxide Synthase (NOS)-CAT639
CAT639

Chemical Structure : CAT639

CAS No.: 2937977-17-6

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CAT639 (CAT 639;CAT-639)

货号: PC-35193Not For Human Use, Lab Use Only.

CAT639 is an improved analog of ATV399 that exhibits improved β-cell viability and insulin secretion in the rat insulin-producing INS1E cells and primary rat dispersed islet cells, inhibits dimerization of iNOS.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    CAT639 is an improved analog of ATV399 that exhibits improved β-cell viability and insulin secretion in the rat insulin-producing INS1E cells and primary rat dispersed islet cells, inhibits dimerization of iNOS.
    CAT639 reduces the production of nitric oxide (NO) by allosterically inhibiting dimerization of the inducible nitric oxide synthase (iNOS) without affecting its mRNA levels.
    CAT639 robustly inhibitscaspase-9 activity at sub-micromolar levels (IC50=0.48 uM), also exhibits potent inhibition of CYP3A4.
    CAT639 protects primary rat islet survival and function impaired by cytokines.

    物理化学性质&存储条件

    分子量 479.551
    分子式 C25H25N3O5S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(4-((2-(6-methylpyridin-3-yl)piperidin-1-yl)sulfonyl)phenyl)benzo[d][1,3]dioxole-5-carboxamide

    参考文献

    1. Zhong L, et al. Br J Pharmacol. 2018 Jun 11. doi: 10.1111/bph.14388.

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