CARM1-IN-1 (Compound 7g)

Chemical Structure : CARM1-IN-1

CAS No.: 1020399-49-8

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货号: PC-43184Not For Human Use, Lab Use Only.

CARM1-IN-1 (Compound 7g) is a potent, selective coactivator-associated arginine methyltransferase 1 (CARM1) with IC50 of 8.6 uM.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

CARM1-IN-1 (Compound 7g) is a potent, selective coactivator-associated arginine methyltransferase 1 (CARM1) with IC50 of 8.6 uM.
CARM1-IN-1 exhibits lower or no activity against a panel of different PRMTs or HKMTs (>80-fold over PRMT1 and SET7).
CARM1-IN-1 inhibits CARM1-mediated methylation of different substrates (PABP1, CA150, SmB, and H3) up to single-digit micromolar level, significantly and dose-dependently reduces the prostate-specific antigen (PSA) promoter activity in human prostate cancer LNCaP cells, does not affect cell viability.

物理化学性质&存储条件

分子量	555.2578
分子式	C26H21Br2NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 35 mg/mL
Chemical Name/SMILES	4-Piperidinone, 3,5-bis[(3-bromo-4-hydroxyphenyl)methylene]-1-(phenylmethyl)-

参考文献

1. Cheng D, et al. J Med Chem. 2011 Jul 14;54(13):4928-32.