CAPCA-1

Chemical Structure : CAPCA-1

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货号: PC-25193Not For Human Use, Lab Use Only.

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生物&药学活性

CAPCA-1 (Cpmpound B) a highly potent cap-dependent endonuclease (CEN) inhibitor, shows broad-spectrum antiviral activity against bunyavirus including Lassa virus (LASV), lymphocytic choriomeningitis virus (LCMV), and Influenza viruses.
CAPCA-1 inhibited LACV-induced CPE in a noncytotoxic range in a dose-dependent manner, with an EC50 value of 0.45 µM in CPE-based assays.
CAPCA-1 inhibits LACV-induced cell death at lower concentrations than the other CEN inhibitors.
CAPCA-1 reduced the LACV-induced CPE and viral growth in SH-SY5Y with EC50 of 0.69 uM.
CAPCA-1 disrupts the post-entry phase of LACV infection.
CAPCA-1 reduces the LACV burden and protects mice from lethal LACV infection.
CAPCA-1 is 100- to 1,000-fold more active in vitro than ribavirin against bunyaviruses, including Lassa virus, lymphocytic choriomeningitis virus (LCMV), and Junin virus.

物理化学性质&存储条件

分子量	459.50
分子式	C26H25N3O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-yl)-5-hydroxy-3-isopropyl-4,6-dioxo-2,3,4,6-tetrahydro-1H-pyrido[2,1-f][1,2,4]triazine-7-carboxylic acid

参考文献

1. Toba S, et al. Proc Natl Acad Sci U S A. 2022 Sep 6;119(36):e2206104119.

2. Konishi K, et al. Antimicrob Agents Chemother. 2025 Jul 23:e0018625.

CAPCA-1

生物&药学活性

物理化学性质&存储条件

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CAPCA-1

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