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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Cyclin-dependent Kinase (CDK)-CAN508
CAN508

Chemical Structure : CAN508

CAS No.: 140651-18-9

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CAN508 (CAN-508)

货号: PC-62864Not For Human Use, Lab Use Only.

CAN508 is a potent, selective CDK9 inhibitor with IC50 of 0.35 uM (CDK9/cyclin T1), displays >35 fold selectivity over CDK1/2/4/7 (IC50=13.5-70 uM).

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50 mg ￥1280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CAN508 is a potent, selective CDK9 inhibitor with IC50 of 0.35 uM (CDK9/cyclin T1), displays >35 fold selectivity over CDK1/2/4/7 (IC50=13.5-70 uM).
CAN508 reduces the frequency of S-phase cells of the cancer cell line HT-29 in antiproliferation assays.
CAN508 decreases phosphorylation of the retinoblastoma protein and the C-terminal domain of RNA polymerase II, inhibits mRNA synthesis, and induces the tumor suppressor protein p53.

物理化学性质&存储条件

分子量 218.22
分子式 C9H10N6O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-[(3,5-diamino-1H-pyrazol-4-yl)azo]-phenol

参考文献

1. Krystof V, et al. J Med Chem. 2006 Nov 2;49(22):6500-9.

2. Kryštof V, et al. Eur J Med Chem. 2011 Sep;46(9):4289-94.

3. Tong Z, et al. Oncotarget. 2017 Apr 25;8(17):28696-28710.

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