CAM833 | RAD51-BRCA2 inhibitor Probechem Biochemicals

Chemical Structure : CAM833

CAS No.: 2758364-02-0

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CAM833 (CAM-833)

货号: PC-38266Not For Human Use, Lab Use Only.

CAM833 (CAM-833) is a potent, specific chemical inhibitor of the RAD51-BRCA2 interaction and RAD51 oligomerization with Kd of 366 nM.

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5 mg	￥3280	In stock
10 mg	￥5280	In stock
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生物&药学活性

CAM833 (CAM-833) is a potent, specific chemical inhibitor of the RAD51-BRCA2 interaction and RAD51 oligomerization with Kd of 366 nM.
CAM833 inhibited RAD51 foci formation 6 h after exposure to 3 Gy IR, in a concentration-dependent manner with an IC50 of 6 uM, causeed a concentration-dependent decrease in RAD51 foci accompanied by increased DNA damage in A549 cells.
CAM833 inhibted RAD51 molecular clustering at DNA damage sites visualized by SMLM, suppressed homologous recombination and potentiated cell-cycle arrest.
CAM833 potentiated the growth suppressive effect of PARP1 inhibition in BRCA2 wild-type cells, as well as dose-dependent growth inhibition when combined with ionizing radiation.

物理化学性质&存储条件

分子量	508.55
分子式	C27H29FN4O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	6-fluoro-N-(2-((2S,4R)-4-hydroxy-2-(((S)-1-(4-methoxy-2-methylphenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-2-oxoethyl)quinoline-2-carboxamide

参考文献

1. Duncan E Scott, et al. Cell Chem Biol. 2021 Jun 17;28(6):835-847.e5.

CAM833 (CAM-833)

生物&药学活性

物理化学性质&存储条件

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CAM833 (CAM-833)

生物&药学活性

物理化学性质&存储条件

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