CAM2602 | Aurora A-TPX2 inhibitor | Probechem Biochemicals

Chemical Structure : CAM2602

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CAM2602 (CAM-2602)

货号: PC-22957Not For Human Use, Lab Use Only.

CAM2602 is a potent, selective small molecule inhibitor of Aurora A-TPX2 protein-protein interaction (PPI), binds to Aurora A and displaces TPX2 from Aurora A with a KD of 19 nM,

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生物&药学活性

CAM2602 is a potent, selective small molecule inhibitor of Aurora A-TPX2 protein-protein interaction (PPI), binds to Aurora A and displaces TPX2 from Aurora A with a KD of 19 nM,
CAM2602 is highly specific to Aurora A over Aurora B.
CAM2602 (20 uM) inhibits Aurora A phosphorylation in Jurkat cells, CAM2602 (200 mg/kg) decreases in the Aurora A P-Thr288 marker.
CAM2602 (100 or 150 mg/kg, daily oral) induces growth suppression in NSG mice bearing subcutaneous, solid tumor xenografts of Jurkat cells, synergizes with paclitaxel to suppress the outgrowth of pancreatic cancer cells.

物理化学性质&存储条件

分子量	484.96
分子式	C23H21ClN4O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-Chloro-3-(pyridin-2-yloxy)phenyl)-N-(N,N-dimethylsulfamoyl)-7-methyl-1H-indole-6-carboxamide

参考文献

1. Stockwell SR, et al. J Med Chem. 2024 Aug 27. doi: 10.1021/acs.jmedchem.4c01165.

CAM2602 (CAM-2602)

生物&药学活性

物理化学性质&存储条件

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CAM2602 (CAM-2602)

生物&药学活性

物理化学性质&存储条件

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