CADD522 | RUNX2 inhibitor | Probechem Biochemicals

Chemical Structure : CADD522

CAS No.: 199735-88-1

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CADD522 (CADD-522)

货号: PC-38159Not For Human Use, Lab Use Only.

CADD522 (CADD-522) is a small molecule that inhibits RUNX2-DNA binding (IC50=10 nM) and decreases RUNX2 transcriptional activity.

规格	价格	库存
25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg	￥3280	In stock
200 mg	￥5480	In stock
1 g		Get quote

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生物&药学活性

CADD522 (CADD-522) is a small molecule that inhibits RUNX2-DNA binding (IC50=10 nM) and decreases RUNX2 transcriptional activity.
CADD522 had no effect on the RUNX2 occupancy in MCF7-Empty cells, CADD522 significantly inhibited RUNX2 enrichment in the MCF7-RUNX2 cells.
CADD522 reduced RUNX2-mediated increases in glucose uptake and decreased the level of CBF-β and RUNX2 phosphorylation at the S451 residue.
The administration of CADD522 into MMTV-PyMT mice resulted in significant delay in tumor incidence and reduction in tumor burden.

物理化学性质&存储条件

分子量	326.173
分子式	C15H13Cl2NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((3,4-dichlorophenyl)carbamoyl)bicyclo[2.2.1]hept-5-ene-2-carboxylic acid

参考文献

1. Kim MS, et al. Oncotarget. 2017 Aug 10;8(41):70916-70940.

2. Kim MS, et al. Oncotarget. 2020 Oct 27;11(43):3863-3885.

CADD522 (CADD-522)

生物&药学活性

物理化学性质&存储条件

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CADD522 (CADD-522)

生物&药学活性

物理化学性质&存储条件

参考文献

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