CAD-031 |CAS:2071209-49-7 Probechem Biochemicals

Chemical Structure : CAD-031

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CAD-031 (CAD031, CAD 031)

货号: PC-61781Not For Human Use, Lab Use Only.

CAD-031 (CAD31) is a novel brain penetrant, J147-derivative that has enhanced neurogenic activity over J147 in human neural precursor cells (NPCs).

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生物&药学活性

CAD-031 (CAD31) is a novel brain penetrant, J147-derivative that has enhanced neurogenic activity over J147 in human neural precursor cells (NPCs).
CAD-031 also stimulates the division of NPCs in the subventricular zone of old APPswe/PS1ΔE9 mice.
CAD-031 rescues primary cortical neurons from oxytosis, and effectively reduce oxidative stress with EC50 of 20 nM.
CAD-031 also prevents loss of energy metabolism that leads to neuron cell death in an in vitro ischemia model with EC50 of 47 nM.
CAD-031 target fatty acid metabolism and inflammation, exhibits therapeutic efficacy on cognitive and physiological parameters in mouse model of AD .

物理化学性质&存储条件

分子量	404.312
分子式	C18H14F6N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Acetic acid, 2,2,2-trifluoro-, (2E)-1-(2,4-dimethylphenyl)-2-[[3-(trifluoromethoxy)phenyl]methylene]hydrazide

参考文献

1. Daugherty D, et al. Alzheimers Res Ther. 2017 Jul 14;9(1):50.

CAD-031 (CAD031, CAD 031)

生物&药学活性

物理化学性质&存储条件

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CAD-031 (CAD031, CAD 031)

生物&药学活性

物理化学性质&存储条件

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