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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Cyclin-dependent Kinase (CDK)-CA224
CA224

Chemical Structure : CA224

CAS No.: 883561-04-4

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CA224 (CA-224;CA 224)

货号: PC-60479Not For Human Use, Lab Use Only.

CA224 is a non-planar analogue of fascaplysin that selectively inhibits CDK4/cyclin D1 with IC50 of 5.5 uM.

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10 mg ￥4280 In stock
25 mg ￥7280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CA224 is a non-planar analogue of fascaplysin that selectively inhibits CDK4/cyclin D1 with IC50 of 5.5 uM.
CA224 does not inhibits CDK2, blocks the growth of cancer cells at G0/G1 phase of the cell cycle, also blocks the cell cycle at G2/M phase.
CA224 also acts as an enhancer of depolymerization for taxol-stabilized tubulin.

物理化学性质&存储条件

分子量 354.453
分子式 C24H22N2O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Biphenyl-4-carboxylic acid [2-(1H-indol-3-yl)-ethyl]-methylamide

参考文献

1. Mahale S, et al. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4272-8.

2. Mahale S, et al. J Med Chem. 2014 Nov 26;57(22):9658-72.

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