欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Immunology/Inflammation-PD-1/PD-L1-CA-170
CA-170

Chemical Structure : CA-170

CAS No.: 1673534-76-3

加入收藏

CA-170 (CA170)

货号: PC-72654Not For Human Use, Lab Use Only.

CA-170 (CA170) is a first-in-class, orally available, tripeptide small-molecule dual antagonist of VISTA/PD-L1, important negative checkpoint regulators of immune activation.

规格 价格 库存 数量
1 mg ￥980 In stock
5 mg ￥2280 In stock
10 mg ￥3780 In stock
25 mg Get quote
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CA-170 (CA170) is a first-in-class, orally available, tripeptide small-molecule dual antagonist of VISTA/PD-L1, important negative checkpoint regulators of immune activation.
CA-170 demonstrated dose-dependent enhancement in the proliferation of PD-L1, PD-L2, and VISTA-inhibited T lymphocytes, and exhibited antitumor effects similar to those of antibodies, including tumor shrinkages and prolonged stable disease without adverse effects.
CA170 has excellent oral bioavailability, a relatively short half-life, and it can dose-dependently enhance the proliferation of T lymphocytes due to its ability to inhibit VISTA.
In syngeneic murine tumor models, the antitumor effects of CA170 were similar to VISTA-blocking antibody.
CA170 was well tolerated in phase I clinical trials and is undergoing phase II clinical trials for lung cancer, head and neck/oral cavity cancer, MSI-H positive cancers, and Hodgkin lymphoma.

物理化学性质&存储条件

分子量 360.33
分子式 C12H20N6O7
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

50 mM in DMSO (18.1 mg/mL)
Chemical Name/SMILES

(((S)-3-amino-1-(3-((S)-1-amino-2-hydroxyethyl)-1,2,4-oxadiazol-5-yl)-3-oxopropyl)carbamoyl)-L-allothreonine

参考文献

1. Musielak B, et al. Molecules. 2019 Aug 1;24(15):2804.

2. Sasikumar PG, et al. Commun Biol. 2021 Jun 8;4(1):699.

3. Li TT, et al. BMC Immunol. 2021 Aug 11;22(1):55.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: