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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Cathepsin-CA-074 methyl ester
CA-074 methyl ester

Chemical Structure : CA-074 methyl ester

CAS No.: 147859-80-1

CA-074 methyl ester (CA074 methyl ester;CA-074Me)

货号: PC-42108Not For Human Use, Lab Use Only.

CA-074 methyl ester is a potent, specific and cell-permeable inhibitor of cathepsin B with Ki of 2-5 nM.

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10 mg ¥1880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CA-074 methyl ester is a potent, specific and cell-permeable inhibitor of cathepsin B with Ki of 2-5 nM.
CA-074 methyl ester displays 10,000-30,000 times greater inhibitory activity than cathepsin H and L.
CA-074 methyl ester improves memory and reduces beta-amyloid in transgenic Alzheimer disease mice.

物理化学性质&存储条件

分子量 397.4659
分子式 C19H31N3O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

H2O: 26.66 mg/mL (Need warming)

Chemical Name/SMILES

L-Proline, N-[[(2S,3S)-3-[(propylamino)carbonyl]-2-oxiranyl]carbonyl]-L-isoleucyl-, methyl ester

参考文献

1. Towatari T, et al. FEBS Lett. 1991 Mar 25;280(2):311-5.

2. Hook VY, et al. J Biol Chem. 2008 Mar 21;283(12):7745-53.

3. Montaser M, et al. Biol Chem. 2002 Jul-Aug;383(7-8):1305-8.

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