C646 | p300 inhibitor | Probechem Biochemicals

Chemical Structure : C646

CAS No.: 328968-36-1

加入收藏

C646 (p300 inhibitor C646)

货号: PC-20778Not For Human Use, Lab Use Only.

C646 is a selective, competitive histone acetyltransferase (HAT) p300 inhibitor with Ki of 400 nM, less potent for other acetyltransferases.

规格	价格	库存
10 mg	￥780	In stock
25 mg	￥1180	In stock
50 mg	￥1880	In stock
100 mg	￥2980	In stock
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

C646 is a selective, competitive histone acetyltransferase (HAT) p300 inhibitor with Ki of 400 nM, less potent for other acetyltransferases.
C646 blocks dynamic acetylation of H3K4me3 globally in mouse and fly cells, and locally across the promoter and start-site of inducible genes in the mouse, thereby disrupting RNA polymerase II association and the activation of genes.
C646 increses caspase-dependent apoptosis involving both extrinsic and intrinsic cell death pathways in androgen-dependent and castration-resistant prostate cancer cells.
C646 inhibits the growth of human melanoma and other tumor cells and promotes cellular senescence.

物理化学性质&存储条件

分子量	445.42
分子式	C24H19N3O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]benzoic acid

参考文献

1. Bowers EM, et al. Chem Biol. 2010 May 28;17(5):471-82.

2. Yan G, et al. J Invest Dermatol. 2013 Oct;133(10):2444-2452.

3. Santer FR, et al. Mol Cancer Ther. 2011 Sep;10(9):1644-55.

4. Crump NT, et al. Proc Natl Acad Sci U S A. 2011 May 10;108(19):7814-9.

C646 (p300 inhibitor C646)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

C646 (p300 inhibitor C646)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.