C644-0303 | Wnt/β-catenin inhibitor | Probechem Biochemicals

Chemical Structure : C644-0303

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C644-0303 (Wnt/β-catenin inhibitor)

货号: PC-38719Not For Human Use, Lab Use Only.

C644-0303 is a novel Wnt/β-catenin signaling inhibitor (IC50=4.2 uM) with antitumor efficacy, inhibits both constitutive and ligand activated Wnt signals and its downstream gene expression.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

C644-0303 is a novel Wnt/β-catenin signaling inhibitor (IC50=4.2 uM) with antitumor efficacy, inhibits both constitutive and ligand activated Wnt signals and its downstream gene expression.
C644‐0303 potently inhibits the cell growth of HCT‐116 (IC50, 17.69 uM), but not a human normal colon epithelial cell line CCD‐841CoN (IC50>50 uM).
C644‐0303 efficiently inhibits proliferation of Wnt‐dependent cancer cell lines (IC50, 10‐25 uM) with little effect on the viability of Wnt‐independent cancer cell lines (IC50>100 uM).
C644‐0303 inhibits β‐catenin activity and its downstream target gene expression, causes cell cycle arrest, induces apoptosis, and inhibits cancer cell migration.
C644‐0303 potently inhibits TCF/LEF activity and modulates β‐catenin activity associated phosphorylation in HCT‐116 cells.
C644‐0303 inhibits the spheroidization and growth of CRC cells both in vitro and in vivo.

物理化学性质&存储条件

分子量	466.589
分子式	C25H23FN2O2S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2E)-3-[(2-ethyl-6-methylphenyl)amino]-3-[(2-fluorobenzyl)sulfanyl]-2-(phenylsulfonyl)acrylonitrile

参考文献

1. Yu Yan, et al. Cancer Sci. 2021 Nov;112(11):4722-4735.