C598-0556 | USP10 inhibitor | Probechem Biochemicals

Chemical Structure : C598-0556

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C598-0556 (USP10 inhibitor)

货号: PC-38771Not For Human Use, Lab Use Only.

C598-0556 is a selective, small molecule inhibitor of USP10, inhibits USP10 comparably to HBX19818 (IC50=10 uM), with no inhibition against USP7 (IC50>100 uM).

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

C598-0556 is a selective, small molecule inhibitor of USP10, inhibits USP10 comparably to HBX19818 (IC50=10 uM), with no inhibition against USP7 (IC50>100 uM).
Small molecule inhibition of USP10 leads to degradation of SYK and targeted killing of activated SYK-driven cells.
C598-0556 induces degradation of SYK in AML cells.

物理化学性质&存储条件

分子量	481.012
分子式	C27H30ClFN4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	9-chloro-N-(3-(4-(2-fluorophenyl)piperazin-1-yl)propyl)-5,6,7,8-tetrahydroacridine-3-carboxamide

参考文献

1. Jing Yang, et al. Br J Cancer. 2020 Apr 14; 122(8): 1175–1184.