C5-benzyl SAHA |CAS:2115700-64-4 Probechem Biochemicals

Chemical Structure : C5-benzyl SAHA

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C5-benzyl SAHA (HDAC6/HDAC8 inhibitor)

货号: PC-62846Not For Human Use, Lab Use Only.

C5-benzyl SAHA is a C5-modified SAHA analog that displays dual selectivity to HDAC6 (IC50=0.27 uM) and HDAC8 (IC50=0.38 uM) over HDAC 1, 2, and 3 (IC50=2.9-5.8 uM).

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生物&药学活性

C5-benzyl SAHA is a C5-modified SAHA analog that displays dual selectivity to HDAC6 (IC50=0.27 uM) and HDAC8 (IC50=0.38 uM) over HDAC 1, 2, and 3 (IC50=2.9-5.8 uM).
C5-benzyl SAHA dose dependently and selectively increases in levels of acetyl-α-tubulin in U937 leukemia cells.

物理化学性质&存储条件

分子量	354.45
分子式	C21H26N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-benzyl-N8-hydroxy-N1-phenyloctanediamide

参考文献

1. Negmeldin AT, et al. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3254-3258.

C5-benzyl SAHA (HDAC6/HDAC8 inhibitor)

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C5-benzyl SAHA (HDAC6/HDAC8 inhibitor)

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物理化学性质&存储条件

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