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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Pregnane X Receptor (PXR)-C2BA-4
C2BA-4

Chemical Structure : C2BA-4

CAS No.: 712333-04-5

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C2BA-4 (C2BA 4)

货号: PC-60008Not For Human Use, Lab Use Only.

C2BA-4 is a potent, specific human Pregnane X receptor (hPXR) activator with EC50 of 49 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    C2BA-4 is a potent, specific human Pregnane X receptor (hPXR) activator with EC50 of 49 nM.
    C2BA-4 activates PXR specifically and more potently than SR12813, induces mRNA expression of hPXR target genes, such as CYPP450 3A4 and 2B6 in primary human hepatocytes.
    C2BA-4 also induces hPXR-mediated in vivo luciferase expression in HGPXR stable bioluminescent cells implanted in mice.

    物理化学性质&存储条件

    分子量 425.931
    分子式 C22H20ClN3O2S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(2-Chlorophenyl)-N-[1-(1-phenylethyl)-1H-benzimidazol-5-yl]methanesulfonamide

    参考文献

    1. Lemaire G, et al. Mol Pharmacol. 2007 Sep;72(3):572-81.

    2. Benod C, et al. Bioorg Med Chem. 2008 Apr 1;16(7):3537-49.

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