C25-140 |CAS:1358099-18-9 Probechem Biochemicals

Chemical Structure : C25-140

CAS No.: 1358099-18-9

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C25-140 (TRAF6-Ubc13 inhibitor C25-140)

货号: PC-35287Not For Human Use, Lab Use Only.

C25-140 is a specific, first-in-class small molecule inhibitor of the TRAF6-Ubc13 interaction, binds TRAF6, inhibits TRAF6-Ubc13 interaction and TRAF6 activity.

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5 mg	￥1580	In stock
10 mg	￥2680	In stock
25 mg	￥4980	In stock
100 mg		Get quote

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生物&药学活性

C25-140 is a specific, first-in-class small molecule inhibitor of the TRAF6-Ubc13 interaction, binds TRAF6, inhibits TRAF6-Ubc13 interaction and TRAF6 activity.
C25-140 effectively reduced TRAF6-mediated ubiquitin chain formation in vitro, impedes NF-κB activation in various immune and inflammatory signaling pathways also in primary human and murine cells.
C25-140 does not effect other E3 ligases (MDM2, TRIM63, ITCH, E6AP and RNF4), also does inhibit E1/E2 reactions.

物理化学性质&存储条件

分子量	457.582
分子式	C26H31N7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-benzylpiperidin-1-yl)-3-(3,5-dimethyl-1-(3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-1H-pyrazol-4-yl)propan-1-one

参考文献

1. Brenke JK, et al. J Biol Chem. 2018 Jun 27. pii: jbc.RA118.002649.

C25-140 (TRAF6-Ubc13 inhibitor C25-140)

生物&药学活性

物理化学性质&存储条件

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C25-140 (TRAF6-Ubc13 inhibitor C25-140)

生物&药学活性

物理化学性质&存储条件

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