C1s inhibitor A1

Chemical Structure : C1s inhibitor A1

CAS No.: 1016866-61-7

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货号: PC-21586Not For Human Use, Lab Use Only.

C1s inhibitor A1 is a selective, competitive inhibitor of complement component C1s with binding Kd of 9.8 uM, competitively inhibits its activity with Ki of 5.8 uM.

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10 mg	￥5280	In stock
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生物&药学活性

C1s inhibitor A1 is a selective, competitive inhibitor of complement component C1s with binding Kd of 9.8 uM, competitively inhibits its activity with Ki of 5.8 uM.
C1s inhibitor A1 dose-dependently inhibits CP activation by heparin-induced immune complexes, CP-driven lysis of Ab-sensitized sheep erythrocytes, CP activation in a pathway-specific ELISA, and cleavage of C2 by C1s.

物理化学性质&存储条件

分子量	281.36
分子式	C16H19N5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(4-phenylpiperazin-1-yl)pyridine-3-carboximidamide

参考文献

1. Xu X, et al. J Immunol. 2023. Dec 27:ji2300630.

C1s inhibitor A1

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