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首页-小分子抑制剂&激动剂-Cytoskeleton/Cell Adhesion Molecules-Integrin-C19-9N
C19-9N

Chemical Structure : C19-9N

CAS No.: 3038591-11-3

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C19-9N

货号: PC-27179Not For Human Use, Lab Use Only.

C19-9N is a potent, orally bioavailable pan-αv/α5β1 integrin antagonist, exhibits high affinity for αvβ3 (Kd=0.55 μM), αvβ5 (Kd=0.61 μM), α5β1 (Kd=0.88 μM), αvβ6 (Kd=0.41 μM) and αvβ8 (Kd=0.86 μM), blocks extracellular matrix (ECM)-integrin interaction.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

C19-9N is a potent, orally bioavailable pan-αv/α5β1 integrin antagonist, exhibits high affinity for αvβ3 (Kd=0.55 μM), αvβ5 (Kd=0.61 μM), α5β1 (Kd=0.88 μM), αvβ6 (Kd=0.41 μM) and αvβ8 (Kd=0.86 μM), blocks extracellular matrix (ECM)-integrin interaction.
C19-9N is a potent inhibitor of prostate cancer cell growth, migration, and invasion in vitro, significantly inhibits the proliferation of AR-positive CRPC (22RV1), AR-negative mCRPC (PC-3), and NEPC (NCI-H660) cells, with IC50 values of 0.49μM, 0.59μM, and 0.37μM, respectively.
C19-9N exerts multi-faceted anti-tumor effects through inducing apoptosis, arresting cell cycle progression, and suppressing integrin-mediated adhesion and migration.
C19-9N inhibits prostate cancer cell stemness and EMT process.
C19-9N significantly inhibits the expression of SRC and STAT3, as well as the phosphorylation of SRC, AKT, and STAT3, leading to downregulation of AR-FL/AR-V7 expression, blockade of their nuclear translocation, and suppression of AR transcriptional activity.
C19-9N (5 or 10 mg/kg, q.d.) dose-dependently suppresses tumor growth in mice bearing TRAMP-C1 xenografts, overcomes enzalutamide resistance in vivo.
C19-9N modulates tumor immune microenvironment by targeting TAMs and CD47 in resistant bone metastases.

物理化学性质&存储条件

分子量 283.34
分子式 C15H17N5O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(E)-N'-((6-methylpyridin-3-yl)methylene)-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazide

参考文献

1. Gu Y, et al. Mol Cancer. 2026 May 13. doi: 10.1186/s12943-026-02686-7.

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