C188-9 (TTI-101) | STAT3 inhibitor | Probechem Biochemicals

Chemical Structure : C188-9

CAS No.: 432001-19-9

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C188-9 (TTI-101, TTI 101)

货号: PC-61162Not For Human Use, Lab Use Only.

C188-9 (TTI-101) is a novel small-molecule STAT3 inhibitor with Ki of 12.4 nM.

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10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3480	In stock
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生物&药学活性

C188-9 (TTI-101) is a novel small-molecule STAT3 inhibitor with Ki of 12.4 nM.
C188-9 inhibits STAT3 binding to its pY-peptide ligand, suppresses cytokine-stimulated pSTAT3, reduces constitutive pSTAT3 activity, and inhibits anchorage dependent and independent growth of in multiple HNSCC cell lines.
C188-9 prevents tumor xenograft growth, modulates many STAT3-regulated genes involved in oncogenesis and radioresistance in vivo.

物理化学性质&存储条件

分子量	471.53
分子式	C27H21NO5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(1',2-dihydroxy-[1,2'-binaphthalen]-4'-yl)-4-methoxybenzenesulfonamide

参考文献

1. Redell MS, et al. Blood. 2011 May 26;117(21):5701-9.

2. Bharadwaj U, et al. Oncotarget. 2016 May 3;7(18):26307-30.

3. Jung KH, et al. Clin Cancer Res. 2017 Sep 15;23(18):5537-5546.

4. Minus MB, et al. Angew Chem Int Ed Engl. 2015 Oct 26;54(44):13085-9.

C188-9 (TTI-101, TTI 101)

生物&药学活性

物理化学性质&存储条件

参考文献

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C188-9 (TTI-101, TTI 101)

生物&药学活性

物理化学性质&存储条件

参考文献

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