C105SR | Cyclophilin inhibitor | Probechem Biochemicals

Chemical Structure : C105SR

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C105SR (C 105SR)

货号: PC-21262Not For Human Use, Lab Use Only.

C105SR is small-molecule cyclophilin inhibitor with IC50 of 5 nM for inhibition of CypD PPIase activity and 9 nM for mitochondrial swelling.

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生物&药学活性

C105SR is small-molecule cyclophilin inhibitor with IC50 of 5 nM for inhibition of CypD PPIase activity and 9 nM for mitochondrial swelling.
C105SR inhibits mPTP opening and prevented cell death in a model of hypoxia/reoxygenation.
C105SR protects against hepatic IRI in vivo by reducing hepatocyte necrosis and apoptosis.

物理化学性质&存储条件

分子量	633.61
分子式	C32H33BrN4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-((S)-2-((R)-2-(benzo[b]thiophen-7-yl)pyrrolidin-1-yl)-1-(5-bromo-2-methoxyphenyl)-2-oxoethyl)-3-((1,2,3,4-tetrahydroquinolin-6-yl)methyl)urea

参考文献

1. Amel Kheyar, et al. JHEP Rep. 2023 Aug 16;5(11):100876.

C105SR (C 105SR)

生物&药学活性

物理化学性质&存储条件

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C105SR (C 105SR)

生物&药学活性

物理化学性质&存储条件

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