C101248 | THIK-1 inhibitor | Probechem Biochemicals

Chemical Structure : C101248

CAS No.: 361368-24-3

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C101248 (C 101248)

货号: PC-49461Not For Human Use, Lab Use Only.

C101248 is the first selective small-molecule inhibitor of tandem pore domain halothane-inhibited K+ channel 1 (THIK-1) with IC50 of 50 nM for both mouse and human THIK-1.

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5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4980	In stock
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100 mg		Get quote

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生物&药学活性

C101248 is the first selective small-molecule inhibitor of tandem pore domain halothane-inhibited K+ channel 1 (THIK-1) with IC50 of 50 nM for both mouse and human THIK-1.
C101248 is selective for THIK-1 and is inactive against K2P family members TREK-1 and TWIK-2, and Kv2.1.
C101248 potently blocked both tonic and ATP-evoked THIK-1 K+ currents in whole-cell patch-clamp recordings of microglia from mouse hippocampal slices.
C101248 had no effect on other constitutively active resting conductance in slices from THIK-1-depleted mice.
C101248 attenuated the NLRP3-dependent release of IL-1β from microglia.

物理化学性质&存储条件

分子量	292.302
分子式	C15H12N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(1-(pyridin-4-ylmethyl)-1H-benzo[d]imidazol-2-yl)-1,2,5-oxadiazol-3-amine

参考文献

1. Bernardino Ossola, et al. Neuropharmacology. 2022 Nov 11;109330

C101248 (C 101248)

生物&药学活性

物理化学性质&存储条件

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C101248 (C 101248)

生物&药学活性

物理化学性质&存储条件

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