C10-AMS

Chemical Structure : C10-AMS

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货号: PC-22699Not For Human Use, Lab Use Only.

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生物&药学活性

C10-AMS is an acyl adenylate mimic and acyl-acyl carrier protein synthetase (AasS, acyl-ACP synthetase) inhibitor with Ki of 0.6 uM, inhibit the AasS-catalyzed loading of fatty acids onto acyl carrier protein (ACP).
C10-AMS is able to effectively stop in vitro loading of decanoic acid onto ACPs from E. coli and V. cholerae by inhibiting AasS from both V. harveyi and V. cholerae.
C10-AMS can be used to study fatty acid recycling in other bacteria as more AasS enzymes continue to be annotated and provides a platform for potential antibiotic development.

物理化学性质&存储条件

分子量	486.59
分子式	C20H34N6O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl decylsulfamate

参考文献

1. Currie MF, et al. Sci Rep. 2020 Oct 20;10(1):17776.

2. Huang H, et al. PLoS Pathog. 2024 Jul 15;20(7):e1012376.

C10-AMS

生物&药学活性

物理化学性质&存储条件

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C10-AMS

生物&药学活性

物理化学性质&存储条件

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