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首页-小分子抑制剂&激动剂-Others-Other Targets-C071-0684
C071-0684

Chemical Structure : C071-0684

CAS No.: 685836-99-1

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C071-0684

货号: PC-23289Not For Human Use, Lab Use Only.

C071-0684 is a potent small molecule inhibitor of CHD1L targeting ATP catalytic activity of chromodomain helicase CHD1L (IC50=17.36 uM, KD=0.5 uM), shows IC50 of 13.0 uM against human HCT116 colorectal cancer cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

C071-0684 is a potent small molecule inhibitor of CHD1L targeting ATP catalytic activity of chromodomain helicase CHD1L (IC50=17.36 uM, KD=0.5 uM), shows IC50 of 13.0 uM against human HCT116 colorectal cancer cells.
C071-0684 demonstrated more potent inhibition than CHD1Li 6.11 (Cat#PC-72745).
C071-0684 showed a significantly higher capacity for inhibiting cell proliferation in MDA-MB-231 cells, which highly express CHD1L, compared to CHD1L-knockdown MDA-MB-231 cells.

物理化学性质&存储条件

分子量 614.72
分子式 C26H29F3N4O4S3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-(tert-butyl)-2-(4-((4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidin-2-yl)sulfonyl)butanamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide

参考文献

1. Zhang C, et al. Int J Biol Macromol. 2024 Oct 18;281(Pt 4):136678.

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