C-type natriuretic peptide | pGC-B activator | Probechem Biochemicals

Chemical Structure : C-type natriuretic peptide

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C-type natriuretic peptide (pGC-B activator CNP)

货号: PC-72558Not For Human Use, Lab Use Only.

C-type natriuretic peptide (CNP, pGC-B activator) is the native particulate guanylyl cyclase B receptor (pGC-B) activator.

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生物&药学活性

C-type natriuretic peptide (CNP, pGC-B activator) is the native particulate guanylyl cyclase B receptor (pGC-B) activator.
CNP induces anti-remodeling actions in the heart and kidney through the generation of the second messenger cGMP.
CNP selectively activates pGC-B and generates cGMP in vitro.
CNP is abundantly expressed in the endothelium and kidneys as well as the heart, but to lesser extent than trial natriuretic peptide (ANP) and b-type natriuretic peptide (BNP).
CNP is produced as a prohormone that is cleaved intracellularly by the enzyme, furin, to yield a 53-AA intermediate form (C53).

物理化学性质&存储条件

分子量	2199.64
分子式	C93H159N27O28S3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	NH2-Gly-Leu-Ser-Lys-Gly-Cys-Phe-Gly-Leu-Lys-Leu-Asp-Arg-Ile-Gly-Ser-Met-Ser-Gly-Leu-Gly-Cys-COOH

参考文献

1. Kuhn M. Physiol Rev. 2016 Apr; 96(2):751-804.

2. Stingo AJ, et al. Am J Physiol. 1992 Oct; 263(4 Pt 2):H1318-21.

C-type natriuretic peptide (pGC-B activator CNP)

生物&药学活性

物理化学性质&存储条件

参考文献

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C-type natriuretic peptide (pGC-B activator CNP)

生物&药学活性

物理化学性质&存储条件

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