C-DIM12 |CAS:178946-89-9 Probechem Biochemicals

Chemical Structure : C-DIM12

CAS No.: 178946-89-9

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C-DIM12 (C-DIM-12;C-DIM 12)

货号: PC-45725Not For Human Use, Lab Use Only.

C-DIM12 is a NR4A2 (Nurr1) activator that inhibits NF-κB-dependent gene expression in glial cells by stabilizing nuclear corepressor CoREST and NCOR2.

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生物&药学活性

C-DIM12 is a NR4A2 (Nurr1) activator that inhibits NF-κB-dependent gene expression in glial cells by stabilizing nuclear corepressor CoREST and NCOR2.
C-DIM12 decreases NF-κB activation and enchances nuclear translocation of Nurr1 primary microglia.

物理化学性质&存储条件

分子量	356.8475
分子式	C23H17ClN2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Indole, 3,3'-[(4-chlorophenyl)methylene]bis-

参考文献

1. De Miranda BR, et al. Mol Pharmacol. 2015 Jun;87(6):1021-34.

2. Hammond SL, et al. Neurosci Lett. 2015 Oct 21;607:83-9.

3. De Miranda BR, et al. J Pharmacol Exp Ther. 2013 Apr;345(1):125-38.

C-DIM12 (C-DIM-12;C-DIM 12)

生物&药学活性

物理化学性质&存储条件

参考文献

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C-DIM12 (C-DIM-12;C-DIM 12)

生物&药学活性

物理化学性质&存储条件

参考文献

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