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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Immune Checkpoints-C-5401331
C-5401331

Chemical Structure : C-5401331

CAS No.: 128-66-5

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C-5401331 (C5401331)

货号: PC-21719Not For Human Use, Lab Use Only.

C-5401331 is a small molecule T-cell immunoglobulin and mucin domain-containing protein 3 (Tim-3) inhibitor, suppresses acute myeloid leukemia (AML) cell proliferation.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    C-5401331 is a small molecule T-cell immunoglobulin and mucin domain-containing protein 3 (Tim-3) inhibitor, suppresses acute myeloid leukemia (AML) cell proliferation.
    C-5401331 inhibits cell viability of THP-1 and HL-60 AML cells with IC50 of 206.6 nM and 318.10 nM respectively.
    C-5401331 inhibits Tim-3 and induces early and late phase apoptosis in AML cells.

    物理化学性质&存储条件

    分子量 332.36
    分子式 C24H12O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    dibenzo[b,def]chrysene-7,14-dione

    参考文献

    1. Al Shahrani M, et al. Med Oncol. 2024 Jan 24;41(3):63.

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