Butyzamide

Chemical Structure : Butyzamide

CAS No.: 1110767-45-7

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货号: PC-25860Not For Human Use, Lab Use Only.

Butyzamide is a potent, specific non-peptidyl activator /agonist of Thrombopoietin (TPO) receptor Mpl, promotes the proliferation of Ba/F3-hMpl cells with EC50 of 10 nM.

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5 mg	￥1880	In stock
10 mg	￥2980	In stock
25 mg	￥4980	In stock
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生物&药学活性

Butyzamide is a potent, specific non-peptidyl activator /agonist of Thrombopoietin (TPO) receptor Mpl, promotes the proliferation of Ba/F3-hMpl cells with EC50 of 10 nM.
Butyzamide does not promotes the proliferation of parental Ba/F3 cells that does not express human Mpl.
Butyzamide shows species specificity for human but not murine Mpl, Butyzamide does not stimulate other cytokine receptors of EPO, G-CSF, GM-CSF and IL-3.
Butyzamide induces phosphorylated JAK2, STAT3, STAT5 and MAPK in Ba/F3-hMpl cells.
Butyzamide induced colony-forming unit-megakaryocyte and polyploid megakaryocytes from human CD34+ hematopoietic progenitor cells.
Butyzamide (3 uM) increased polyploid megakaryocytes in a similar manner to 1 nM rhTPO.
Butyzamide (10 or 50 mg/kg once daily for 20 daysincreased human platelets in FL-CD34+-transplanted NOG mice.

物理化学性质&存储条件

分子量	591.54
分子式	C29H32Cl2N2O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-3-(2,6-Dichloro-4-((4-(3-(2,2-dimethyl-1-propoxypropyl)-2-methoxyphenyl)thiazol-2-yl)carbamoyl)phenyl)-2-methylacrylic acid

参考文献

1. Nogami W, et al. Haematologica. 2008 Oct;93(10):1495-504.

Butyzamide

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Butyzamide

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