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首页-小分子抑制剂&激动剂-Others-Other Targets-Bufotalin
Bufotalin

Chemical Structure : Bufotalin

CAS No.: 471-95-4

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Bufotalin

货号: PC-26260Not For Human Use, Lab Use Only.

Bufotalin is a steroid lactone isolated from Venenum Bufonis with potently antitumor activities, a selective and potent inhibitor of COL1A1-high NSCLC.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Bufotalin is a steroid lactone isolated from Venenum Bufonis with potently antitumor activities, a selective and potent inhibitor of COL1A1-high NSCLC.
Bufotalin shows inhibitory effect on the viability of doxorubicin-induced multidrug resistant liver cancer cells (R-HepG2) than that of their parent cells HepG2.
Bufotalin induces cell cycle arrest at G(2)/M phase through down-regulation of Aurora A, CDC25, CDK1, cyclin A and cyclin B1, as well as up-regulation of p53 and p21.
Bufotalin significantly inhibited the growth of xenografted R-HepG2 cells.
Bufotalin physically engages COL1A1, triggering its post-transcriptional down-regulation and concomitantly crippling malignant fitness.
Bufotalin simultaneously disables the PTEN/AKT/mTOR and Ras/MEK/ERK cascades, enforces G2-M arrest via Cyclin B1/CDK1 dysregulation, and quells epithelial-to-mesenchymal transition by restoring E-cadherin while repressing N-cadherin, MMP3, and MMP9.

物理化学性质&存储条件

分子量 444.57
分子式 C26H36O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(3S,5R,8R,9S,10S,13R,14S,16S,17R)-3,14-Dihydroxy-10,13-dimethyl-17-(2-oxo-2H-pyran-5-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-16-yl acetate

参考文献

1. Zhang Y, et al. Eur J Pharmacol. 2026 Feb 15;1015:178601.

2. Zhu Z, et al. Aging (Albany NY). 2024 May 28;16(10):9264-9279.

3. Zhang DM, et al. Eur J Pharmacol. 2012 Oct 5;692(1-3):19-28.

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