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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Heat Shock Protein (HSP)-Bufalin
Bufalin

Chemical Structure : Bufalin

CAS No.: 465-21-4

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Bufalin (AHSA1 inhibitor)

货号: PC-72659Not For Human Use, Lab Use Only.

Bufalin is a highly toxic, effective anti-cancer compound, targets Hsp90 cochaperone AHSA1 (Aha1, Activator of HSP90 ATPase Activity 1).

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10 mg ￥1380 In stock
25 mg ￥2280 In stock
50 mg ￥3780 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Bufalin is a highly toxic, effective anti-cancer compound, targets Hsp90 cochaperone AHSA1 (Aha1, Activator of HSP90 ATPase Activity 1).
AHSA1-K137 as the specific binding site of Bufalin on AHSA1, mutation of which decreased the interaction of AHSA1 with HSP90A and suppressed the function of AHSA1 on mediating CDK6 and PSMD2.
Bufalin is an anticancer molecular extract from traditional Chinese medicine, exerts significantly experimental anticancer effects in various cancers including MM by inducing cellular apoptotic, autophagic and anti-inflammatory activities.
The potential side effects and toxicities of Bufalin such as hematological, gastrointestinal, mucocutaneous and cardiovascular adverse reactions limit the clinical setting of Bufalin.

物理化学性质&存储条件

分子量 386.5
分子式 C24H34O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-((3S,5R,8R,9S,10S,13R,14S,17R)-3,14-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2H-pyran-2-one

参考文献

1. Gu C, et al. J Exp Clin Cancer Res. 2022 Jan 6;41(1):11.

2. Zhang X, et al. Am J Chin Med. 2020; 48(7):1633-1650.

3. Cheng CS, et al. Cancer Cell Int. 2019; 19():92.

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