Brivanib alaninate |CAS:649735-63-7 Probechem Biochemicals

Chemical Structure : Brivanib alaninate

CAS No.: 649735-63-7

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Brivanib alaninate (BMS-582664, BMS582664)

货号: PC-42533Not For Human Use, Lab Use Only.

Brivanib alaninate is prodrug of Brivanib (BMS-582664), which is a dual inhibitor of VEGFR2 and FGFR1 with IC50 of 25 nM and 148 nM respectively.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3280	In stock
50 mg	￥5280	In stock
100 mg		Get quote

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生物&药学活性

Brivanib alaninate is prodrug of Brivanib (BMS-582664), which is a dual inhibitor of VEGFR2 and FGFR1 with IC50 of 25 nM and 148 nM respectively.
Brivanib alaninate exhibits improved aqueous solubility and oral bioavailability of the parent compound.

物理化学性质&存储条件

分子量	441.4555
分子式	C22H24FN5O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	L-Alanine, (1R)-2-[[4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-1-methylethyl ester

参考文献

1. Cai ZW, et al. J Med Chem. 2008 Mar 27;51(6):1976-80.

2. Huynh H, et al. Clin Cancer Res. 2008 Oct 1;14(19):6146-53.

3. Patel RR, et al. Eur J Cancer. 2010 Jun;46(9):1537-53.

Brivanib alaninate (BMS-582664, BMS582664)

生物&药学活性

物理化学性质&存储条件

参考文献

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Brivanib alaninate (BMS-582664, BMS582664)

生物&药学活性

物理化学性质&存储条件

参考文献

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