Brivanib (BMS540215) |CAS:649735-46-6 Probechem Biochemicals

Chemical Structure : Brivanib (BMS540215)

CAS No.: 649735-46-6

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Brivanib (BMS540215) (BMS-540215, BMS540215)

货号: PC-42534Not For Human Use, Lab Use Only.

Brivanib (BMS540215) is a potent, dual inhibitor of VEGFR2 and FGFR1 with IC50 of 25 nM and 148 nM respectively.

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5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg	￥4580	In stock
100 mg		Get quote

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生物&药学活性

Brivanib (BMS540215) is a potent, dual inhibitor of VEGFR2 and FGFR1 with IC50 of 25 nM and 148 nM respectively.
Brivanib (BMS540215) shows weak activity for VEGFR1 (IC50=380 nM), and no significant activity on EGFR, PDGFRβ, Lck, etc.
Brivanib (BMS540215) demonstrates robust in vivo activity in human tumor xenograft models.

物理化学性质&存储条件

分子量	370.3776
分子式	C19H19FN4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 50 mg/mL
Chemical Name/SMILES	2-Propanol, 1-[[4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-, (2R)-

参考文献

1. Bhide RS, et al. J Med Chem. 2006 Apr 6;49(7):2143-6.

2. Bhide RS, et al. Mol Cancer Ther. 2010 Feb;9(2):369-78.

3. Huynh H, et al. Clin Cancer Res. 2008 Oct 1;14(19):6146-53.

Brivanib (BMS540215) (BMS-540215, BMS540215)

生物&药学活性

物理化学性质&存储条件

参考文献

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Brivanib (BMS540215) (BMS-540215, BMS540215)

生物&药学活性

物理化学性质&存储条件

参考文献

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