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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-CMV-Brincidofovir
Brincidofovir

Chemical Structure : Brincidofovir

CAS No.: 444805-28-1

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Brincidofovir (CMX001, Cidofovir HDP, HDP-CDV)

货号: PC-62054Not For Human Use, Lab Use Only.

Brincidofovir (CMX 001, Cidofovir HDP) is a lipid conjugate of the acyclic nucleotide phosphonate, cidofovir that shows activity against all five families of dsDNA viruses that cause human morbidity and mortality, including orthopoxviruses such as variola virus, the cause of human smallpox.

规格 价格 库存 数量
10 mg ￥1280 In stock
25 mg ￥1980 In stock
50 mg ￥3480 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Brincidofovir (CMX001, Cidofovir HDP) is a lipid conjugate of the acyclic nucleotide phosphonate, cidofovir that shows activity against all five families of dsDNA viruses that cause human morbidity and mortality,including cytomegalovirus (CMV), adenovirus (ADV), varicella zoster virus, HSV, polyomaviruses, papillomaviruses, poxviruses, and mixed double-stranded DNA virus infections.
Brincidofovir has a number of advantages for treatment of smallpox in an emergency including greater potency in vitro against all dsDNA viruses that cause human disease, a high genetic barrier to resistance, convenient oral administration as a tablet or liquid, and no evidence to date of nephrotoxicity in either animals or humans.

物理化学性质&存储条件

分子量 561.701
分子式 C27H52N3O7P
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(hexadecyloxy)propyl hydrogen ((((S)-1-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-hydroxypropan-2-yl)oxy)methyl)phosphonate

参考文献

1. Toth K, et al. Proc Natl Acad Sci U S A. 2008 May 20;105(20):7293-7.

2. Lanier R, et al. Viruses. 2010 Dec;2(12):2740-2762.

3. McMullan LK, et al. Antiviral Res. 2016 Jan;125:71-8.

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