Brilaroxazine |CAS:1239729-06-6 Probechem Biochemicals

Chemical Structure : Brilaroxazine

CAS No.: 1239729-06-6

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Brilaroxazine (RP5063, RP-5063)

货号: PC-63187Not For Human Use, Lab Use Only.

RP-5063 (Brilaroxazine) is a multimodal dopamine and serotonin modulator with partial agonist activity at DA D2, D3, D4, 5-HT1A, and 5-HT2ARs, and antagonist activity at 5-HT2B, 5-HT6 and 5-HT7Rs.

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5 mg	￥2480	In stock
10 mg	￥3980	In stock
25 mg	￥5880	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

RP-5063 (Brilaroxazine) is a multimodal dopamine and serotonin modulator with partial agonist activity at DA D2, D3, D4, 5-HT1A, and 5-HT2ARs, and antagonist activity at 5-HT2B, 5-HT6 and 5-HT7Rs.
RP-5063 produces dose-dependent reductions in pulmonary blood vessel wall thickness and proportion of muscular vessels, blocks MCT-induced increases in the plasma cytokines TNFα, IL-1β, and IL-6 in vivo.
RP-5063 prevents Sugen 5416-hypoxia-induced pulmonary arterial hypertension in rats.
RP-5063 improves declarative memory and psychosis in mouse models of schizophrenia.

物理化学性质&存储条件

分子量	450.36
分子式	C22H25Cl2N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-2H-benzo[b][1,4]oxazin-3(4H)-one

参考文献

1. Bhat L, et al. Eur J Pharmacol. 2017 Sep 5;810:83-91.

2. Rajagopal L, et al. Behav Brain Res. 2017 Aug 14;332:180-199.

3. Bhat L, et al. Eur J Pharmacol. 2017 Sep 5;810:92-99.

Brilaroxazine (RP5063, RP-5063)

生物&药学活性

物理化学性质&存储条件

参考文献

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Brilaroxazine (RP5063, RP-5063)

生物&药学活性

物理化学性质&存储条件

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