Brigimadlin (BI 907828) | MDM2-p53 antagonist | Probechem Biochemicals

Chemical Structure : Brigimadlin

CAS No.: 2095116-40-6

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Brigimadlin (BI 907828, BI-907828)

货号: PC-20668Not For Human Use, Lab Use Only.

BI 907828 ( Brigimadlin) is an orally available inhibitor of murine double minute 2 (MDM2) with potential antineoplastic activity, BI 907828 binds to MDM2 protein and prevents its binding to p53.

规格	价格	库存
1 mg	￥2880	In stock
5 mg	￥4980	In stock
10 mg	￥7580	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Brigimadlin (BI 907828) is an orally available inhibitor of murine double minute 2 (MDM2) with potential antineoplastic activity, BI 907828 binds to MDM2 protein and prevents its binding to p53.
BI 907828 decreases viability and induces cell death at picomolar concentrations, in both MDM2 amplified and normal copy number, TP53 wild-type BTSC lines.
BI 907828 (50mg/kg p.o.) treatment resulted in strong activation of p53 target genes p21 and MIC1 in orthotopic tumor-bearing SCID mice.

物理化学性质&存储条件

分子量	591.46
分子式	C31H25Cl2FN4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S,3'S,3a'S,10a'S)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-1'-(cyclopropylmethyl)-6'-methyl-2-oxo-3',3a',10',10a'-tetrahydro-1'H-spiro[indoline-3,2'-pyrrolo[2',3':4,5]pyrrolo[1,2-b]indazole]-7'-carboxylic acid

参考文献

1. Xiaoguang Hao, et al. Neuro Oncol. 2022 Dec 15;noac271.

Brigimadlin (BI 907828, BI-907828)

生物&药学活性

物理化学性质&存储条件

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Brigimadlin (BI 907828, BI-907828)

生物&药学活性

物理化学性质&存储条件

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