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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-Raf-Braftide
Braftide

Chemical Structure : Braftide

CAS No.: 2411851-64-2

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Braftide

货号: PC-24277Not For Human Use, Lab Use Only.

Braftide is a potent allosteric RAF kinase dimer disruptor, inhibits RAF dimerization by targeting the conserved RAF dimer interface, inhibits wild-type BRAF and oncogenic BRAF G469A with IC50 of 364 nM and 172 nM, respectively.

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50 mg ￥2180 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Braftide is a potent allosteric RAF kinase dimer disruptor, inhibits RAF dimerization by targeting the conserved RAF dimer interface, inhibits wild-type BRAF and oncogenic BRAF G469A with IC50 of 364 nM and 172 nM, respectively.
Braftide inhibits MAPK signaling pathway.
Braftide inhibits proliferation of KRAS mutant tumor cells (EC50= 7.1 and 6.6 μM, for HCT116 and HCT-15).

物理化学性质&存储条件

分子量 1243.54
分子式 C57H94N16O13S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

L-Methionine, L-threonyl-L-arginyl-L-histidyl-L-valyl-L-asparaginyl-L-isoleucyl-L-leucyl-L-leucyl-L-phenylalanyl-

参考文献

1. Gunderwala AY, et al. ACS Chem Biol. 2019 Jul 19;14(7):1471-1480.

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