Box5 |CAS:1206604-29-6 Probechem Biochemicals

Chemical Structure : Box5

CAS No.: 1206604-29-6

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Box5 (Wnt5a antagonist Box5)

货号: PC-35020Not For Human Use, Lab Use Only.

Box5 is a Wnt5a-derived N-butyloxycarbonyl hexapeptide (t-Boc-Met-Asp-Gly-Cys-Glu-Leu), acts as an Wnt5a antagonist.

规格	价格	库存
5 mg	￥1480	In stock
10 mg	￥2280	In stock
25 mg	￥3780	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Box5 is a Wnt5a-derived N-butyloxycarbonyl hexapeptide (t-Boc-Met-Asp-Gly-Cys-Glu-Leu), acts as an Wnt5a antagonist.
Box5 abolishes exogenous Wnt5a stimulation of A2058 cells increased adhesion, migration and invasion, all crucial components of tumor metastasis.
Box5 also inhibits the basal migration and invasion of Wnt5a-expressing HTB63 melanoma cells, antagonizes the effects of Wnt5a on melanoma cell migration and invasion by directly inhibiting Wnt5a-induced PKC and Ca(2+) signaling.

物理化学性质&存储条件

分子量	766.88
分子式	C30H50N6O13S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[(1,1-Dimethylethoxy)carbonyl]-L-methionyl-L-alpha-aspartylglycyl-L-cysteinyl-L-alpha-glutamyl-L-leucine

参考文献

1. Jenei V, et al. Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19473-8.

2. Linnskog R, et al. Oncotarget. 2016 Jun 21;7(25):37790-37802.

3. Yuan S, et al. J Neuroimmune Pharmacol. 2012 Dec;7(4):904-13.

4. Ackers I, et al. Cardiovasc Pathol. 2018 May-Jun;34:1-8.

Box5 (Wnt5a antagonist Box5)

生物&药学活性

物理化学性质&存储条件

参考文献

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Box5 (Wnt5a antagonist Box5)

生物&药学活性

物理化学性质&存储条件

参考文献

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