Bomedemstat ditosylate (IMG-7289) | LSD1 inhibitor | Probechem Biochemicals

Chemical Structure : Bomedemstat ditosylate

CAS No.: 1990504-72-7

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Bomedemstat ditosylate (IMG-7289 ditosylate)

货号: PC-24550Not For Human Use, Lab Use Only.

Bomedemstat ditosylate (IMG-7289) is a potent, selective, irreversible and orally active LSD1 (KDM1A) inhibitor, increases H3K4 and H3K9 methylation.

规格	价格	库存
2 mg	￥1280	In stock
5 mg	￥2180	In stock
10 mg	￥3580	In stock
25 mg	￥5580	In stock
50 mg		Get quote

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生物&药学活性

Bomedemstat ditosylate (IMG-7289) is a potent, selective, irreversible and orally active LSD1 (KDM1A) inhibitor, increases H3K4 and H3K9 methylation.
Bomedemstat (IMG-7289) potentiated responses to PD-1 inhibition in a syngeneic model of SCLC, resulting in increased CD8+ T-cell infiltration and strong tumor growth inhibition.
Bomedemstat (IMG-7289) increased MHC class I expression in mouse SCLC tumor cells in vivo and augmented MHC-I induction by IFNγ and increased killing by tumor-specific T cells in cell culture.
Bomedemstat (IMG-7289) inhibits the production of inflammatory cytokines, impairs self-renewal and proliferation of neoplastic stem cells, and shows significant disease-modifying activities in multiple non-clinical models of myelofibrosis.

物理化学性质&存储条件

分子量	864.02
分子式	C42H50FN7O8S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((S)-5-(((1R,2S)-2-(4-Fluorophenyl)cyclopropyl)amino)-1-(4-methylpiperazin-1-yl)-1-oxopentan-2-yl)-4-(1H-1,2,3-triazol-1-yl)benzamide bis(4-methylbenzenesulfonate)

参考文献

1. Jutzi JS, et al. Hemasphere. 2018 Jun 8;2(3):e54.

2. Hiatt JB, et al. Clin Cancer Res. 2022 Oct 14;28(20):4551-4564.

Bomedemstat ditosylate (IMG-7289 ditosylate)

生物&药学活性

物理化学性质&存储条件

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Bomedemstat ditosylate (IMG-7289 ditosylate)

生物&药学活性

物理化学性质&存储条件

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