Bisthianostat | HDAC inhibitor | Probechem Biochemicals

Chemical Structure : Bisthianostat

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Bisthianostat (CF367)

货号: PC-24619Not For Human Use, Lab Use Only.

Bisthianostat (CF367) is an orally bioavailable pan-inhibitor of human histone deacetylase (HDAC) with IC50 of 0.07, 0.26 and 0.79 uM for HDAC1, HDAC2 and HDAC6 respectively.

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生物&药学活性

Bisthianostat (CF367) is an orally bioavailable pan-inhibitor of human histone deacetylase (HDAC) with IC50 of 0.07, 0.26 and 0.79 uM for HDAC1, HDAC2 and HDAC6 respectively.
Bisthianostat (CF367) displays potent activity against nine HDACs except HDAC7 and HDAC9.
Bisthianostat (CF367) induces histone acetylation in MEF cells and apoptosis in T cells.
Bisthianostat (CF367) (10 mg/kg) alleviates clinical symptoms of EAE in several autoimmune animal models.

物理化学性质&存储条件

分子量	366.45
分子式	C15H18N4O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-cyclopropyl-N-[5-(hydroxyamino)-5-oxopentyl]-2-(1,3-thiazol-2-yl)-1,3-thiazole-4-carboxamide

参考文献

1. Fei Chen, et al. ACS Med Chem Lett. 2014 Apr 4;5(6):628-33.

2. Patent WO2022058405 A2.

Bisthianostat (CF367)

生物&药学活性

物理化学性质&存储条件

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Bisthianostat (CF367)

生物&药学活性

物理化学性质&存储条件

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