Bis-T-23 |CAS:171674-76-3 Probechem Biochemicals

Chemical Structure : Bis-T-23

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Bis-T-23 (AG1717, Ryngo 1-23)

货号: PC-63280Not For Human Use, Lab Use Only.

Bis-T-23 is a small molecule that stimulates actin-dependent dynamin oligomerization and promotes dynamin GTPase activity, increases actin polymerization in injured podocytes.

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生物&药学活性

Bis-T-23 (Ryngo 1-23) is a small molecule that stimulates actin-dependent dynamin oligomerization and promotes dynamin GTPase activity, increases actin polymerization in injured podocytes.
Bis-T-23 ameliorates or prevents proteinuria and diminishes mesangial matrix expansion in diverse genetic and chronic models of glomerular disease in rodents.
Bis-T-23 improves renal health in diverse models of both transient kidney disease and CKD.

物理化学性质&存储条件

分子量	480.433
分子式	C23H20N4O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2E,2'E)-N,N'-1,3-Propanediylbis[2-cyano-3-(3,4,5-trihydroxyphenyl)-2-propenamide]

参考文献

1. Schiffer M, et al. Nat Med. 2015 Jun;21(6):601-9.

2. Del Nogal-Avila M, et al. Am J Physiol Renal Physiol. 2016 Jul 1;311(1):F63-5.

3. Gu C, et al. J Am Soc Nephrol. 2017 Feb;28(2):446-451.

Bis-T-23 (AG1717, Ryngo 1-23)

生物&药学活性

物理化学性质&存储条件

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Bis-T-23 (AG1717, Ryngo 1-23)

生物&药学活性

物理化学性质&存储条件

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