BioA inhibitor C48

Chemical Structure : BioA inhibitor C48

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货号: PC-25836Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

BioA inhibitor C48 is a potent and selective inhibitor of bacterial aminotransferase BioA, a key enzyme in bacterial biotin biosynthesis, with Ki of 200 pM, displays sub-micromolar MICs against Mycobacterium tuberculosis (Mtb, H37Rv MIC50=93 nM) and nontuberculous mycobacteria.
C48 induces cell envelope stress and membrane remodeling, mimicking biotin starvation.
C48 has IC50 of 34 nM in BioA inhibition assays.
C48 reduced Mtb burden in lungs and spleen in murine infection models.

物理化学性质&存储条件

分子量	418.27
分子式	C19H17BrFN3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(4-(3-bromo-4-fluorobenzoyl)piperazin-1-yl)-5,6-dihydro-7H-cyclopenta[c]pyridin-7-one

参考文献

1. Qiang Liu, et al. bioRxiv [Preprint]. 2025 Sep 24:2025.09.24.678246.