Bio-AMS

Chemical Structure : Bio-AMS

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货号: PC-23818Not For Human Use, Lab Use Only.

Bio-AMS is a potent bacterial biotin protein ligase (BPL) inhibitor, possesses selective activity against Mycobacterium tuberculosis (Mtb) and inhibits fatty acid and lipid biosynthesis.

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生物&药学活性

Bio-AMS is a potent bacterial biotin protein ligase (BPL) inhibitor, possesses selective activity against Mycobacterium tuberculosis (Mtb) and inhibits fatty acid and lipid biosynthesis.
In biotin-free medium, the BPL inhibitor Bio-AMS was bactericidal at a concentration of 5 µM.
Bio-AMS inhibited growth of Mtb in a concentration-dependent manner in Mtb-infected mouse macrophages in vitro.
Bio-AMS enhances the activity of rifampicin and ethambutol in vitro. can prevent growth of both drug-sensitive and drug-resistant Mtb in vitro.

物理化学性质&存储条件

分子量	571.63
分子式	C20H29N9O7S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(N-(((2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)sulfamoyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide

参考文献

1. Tiwari D, et al. Sci Transl Med. 2018 Apr 25;10(438):eaal1803.

2. Bockman MR, et al. ACS Infect Dis. 2018 Jul 13;4(7):1102-1113.

Bio-AMS

生物&药学活性

物理化学性质&存储条件

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Bio-AMS

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