欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Immunology/Inflammation-Interleukin Receptor-Bindarit
Bindarit

Chemical Structure : Bindarit

CAS No.: 130641-38-2

加入收藏

Bindarit (AF2838)

货号: PC-20616Not For Human Use, Lab Use Only.

Bindarit (AF2838) is a selective inhibition of inflammatory chemokine MCP-1/CCL2, MCP-3/CCL7, and MCP-2/CCL8, shows immunosuppressive effects anti-inflammatory activity.

规格 价格 库存 数量
10 mg ￥1980 In stock
25 mg ￥2980 In stock
50 mg ￥4880 In stock
100 mg ￥7580 In stock
1 g Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Bindarit (AF2838) is a selective inhibition of inflammatory chemokine MCP-1/CCL2, MCP-3/CCL7, and MCP-2/CCL8, shows immunosuppressive effects anti-inflammatory activity.
Bindarit displays no effect on other CC and CXC chemokines such as MIP-1α/CCL3, MIP-1β/CCL4, MIP-3/CCL23, RANTES/CCL5, and IL8/CXCL8.
Bindarit dose-dependently inhibits MCP-1 and TNF-alpha production induced in vitro in monocytes by LPS and Candida albicans, does not affect the production of the cytokines IL-1, IL-6, or the chemokines IL-8, MIP-1alpha and RANTES.
Bindarit reduces monocyte recruitment and local MCP-1 production, induced by carrageenan or IL-1 injection.
Bindarit protects mice against trinitrobenzene sulfonic acid-induced colitis.
Bindarit reduces tumor growth and macrophage recruitment, rendering necrotic tumor masses in melanoma-bearing mice.

物理化学性质&存储条件

分子量 324.38
分子式 C19H20N2O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-[(1-benzyl-1H-indazol-3-yl)methoxy]-2-methylpropanoic acid

参考文献

1. Gazzaniga S, et al. J Invest Dermatol. 2007 Aug;127(8):2031-41.

2. Grassia G, et al. Cardiovasc Res. 2009 Dec 1;84(3):485-93.

3. Bhatia M, et al. Inflamm Res. 2008 Oct;57(10):464-71.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: